Document and Entity Information Document Type Document Quarterly Report Document Transition Report Document Period End Date Entity File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, City or Town Entity Address, Country Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company Entity Shell Company Entity Common Stock, Shares Outstanding Entity Central Index Key Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Condensed Consolidated Balance Sheets Statement [Table] Statement [Line Items] Assets [Abstract] Assets Assets, Current [Abstract] Current assets: Cash and Cash Equivalents, at Carrying Value Cash and cash equivalents Marketable Securities, Current Marketable securities Prepaid Expense and Other Assets, Current Prepaid expenses and other current assets Total Assets, Current Total current assets Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Operating Lease, Right-of-Use Asset Operating lease right-of-use assets Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities and stockholders' equity Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Operating Lease, Liability, Current Lease liabilities, current Operating lease liabilities, current Other Liabilities, Current Other current liabilities Total Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Lease liabilities, non-current Operating lease liabilities, net of current portion Liabilities Total liabilities Commitments and Contingencies Commitments and contingencies (Note 10) Stockholders' Equity Attributable to Parent [Abstract] Stockholders' equity: Preferred Stock, Value, Issued Preferred stock, $0.0001 par value; 10,000,000 shares authorized as of March 31, 2023 and December 31, 2022; no shares issued and outstanding as of March 31, 2023 and December 31, 2022. Common Stock, Value, Issued Common stock, $0.0001 par value; 490,000,000 shares authorized as of March 31, 2023 and December 31, 2022; 40,696,563 and 40,601,648 shares issued as of March 31, 2023 and December 31, 2022, respectively; 40,438,320 and 40,287,097 shares outstanding as of March 31, 2023 and December 31, 2022, respectively. Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive loss Retained Earnings (Accumulated Deficit) Accumulated deficit Stockholders' Equity Attributable to Parent Balances, at End of period Balances, at Beginning of period Total stockholders' equity Liabilities and Equity Total liabilities and stockholders' equity Preferred Stock, Par or Stated Value Per Share Preferred stock, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred stock, authorized (in shares) Preferred Stock, Shares Issued Preferred stock, issued (in shares) Preferred Stock, Shares Outstanding Preferred stock, outstanding (in shares) Common Stock, Par or Stated Value Per Share Common stock, par value (in dollars per share) Common Stock, Shares Authorized Common stock, authorized (in shares) Common Stock, Shares, Issued Common stock, issued (in shares) Common Stock, Shares, Outstanding Common stock, outstanding (in shares) Condensed Consolidated Statements of Operations Operating Expenses [Abstract] Operating expenses: Research and Development Expense Research and development General and Administrative Expense General and administrative Operating Expenses Total operating expenses Operating Income (Loss) Loss from operations Nonoperating Income (Expense) [Abstract] Other income: Investment Income, Interest Interest income Other Nonoperating Income (Expense) Other income Nonoperating Income (Expense) Total other income Net Income (Loss) Attributable to Parent Net loss Net loss attributable to common stockholders Net loss Earnings Per Share, Basic Net loss per share attributable to common stockholders, basic Earnings Per Share, Diluted Net loss per share attributable to common stockholders, diluted Weighted Average Number of Shares Outstanding, Basic Weighted average shares used to compute net loss per share, basic Weighted Average Number of Shares Outstanding, Diluted Weighted average shares used to compute net loss per share, diluted Condensed Consolidated Statements of Comprehensive Loss Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive gain (loss): Other Comprehensive Income (Loss), Available-for-sale Securities Adjustment, Net of Tax, Portion Attributable to Parent Net unrealized gain (loss) on marketable securities Comprehensive Income (Loss), Net of Tax, Attributable to Parent Total comprehensive loss Condensed Consolidated Statements of Stockholders' Equity Equity Components [Axis] Equity Component [Domain] Common Stock Additional Paid-in Capital Accumulated Other Comprehensive (Loss) Gain Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Shares, Outstanding Balances, at End of period (in shares) Balances, at Beginning of period (in shares) Value of options vested. Excludes equity instruments other than options, for example, but not limited to, share units, stock appreciation rights, restricted stock. Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Value Vesting of early exercised stock options Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares Vesting of early exercised stock options (in shares) Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period Vested (in shares) Vesting of restricted stock awards (in shares) Stock Issued During Period, Value, Stock Options Exercised Exercise of stock options Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period Exercised (in shares) Exercise of stock options (in shares) APIC, Share-based Payment Arrangement, Increase for Cost Recognition Stock-based compensation expense APIC, Share-based Payment Arrangement, ESPP, Increase for Cost Recognition Employee stock purchase plan expense Condensed Consolidated Statements of Cash Flows Net Cash Provided by (Used in) Operating Activities [Abstract] Cash flows from operating activities: Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net loss Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract] Adjustments to reconcile net loss to net cash used in operating activities: Depreciation, Depletion and Amortization Depreciation and amortization expense Operating Lease, Right-of-Use Asset, Amortization Expense Non-cash lease expense Accretion (Amortization) of Discounts and Premiums, Investments Premium amortization and discount accretion on marketable securities, net Share-based Payment Arrangement, Noncash Expense Stock-based compensation expense, including employee stock purchase plan expense Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: Increase (Decrease) in Prepaid Expense and Other Assets Prepaid expenses and other current assets Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Other Current Liabilities Other current liabilities Increase (Decrease) in Operating Lease Liability Operating lease liabilities Net Cash Provided by (Used in) Operating Activities Net cash used in operating activities Net Cash Provided by (Used in) Investing Activities [Abstract] Cash flows from investing activities: Payments to Acquire Property, Plant, and Equipment Purchase of equipment Proceeds from Sale and Maturity of Marketable Securities Maturities of marketable securities Payments to Acquire Marketable Securities Purchases of marketable securities Net Cash Provided by (Used in) Investing Activities Net cash provided by investing activities Net Cash Provided by (Used in) Financing Activities [Abstract] Cash flows from financing activities: Proceeds from Stock Options Exercised Proceeds from exercise of stock options Net Cash Provided by (Used in) Financing Activities Net cash provided by financing activities Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect Net increase in cash and cash equivalents Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents Cash and cash equivalents at end of period Cash and cash equivalents at beginning of period Noncash Investing and Financing Items [Abstract] Supplemental disclosure of non-cash investing and financing activities: The amount of prepaid expenses and other current liabilities reclassified into other assets. Reclassification Of Prepaid Expenses And Other Current Liabilities Into Other Assets Reclassification of prepaid expenses and other current liabilities into other assets Nature of the Business and Basis of Presentation Business Description and Basis of Presentation [Text Block] Nature of the Business and Basis of Presentation Summary of Significant Accounting Policies Significant Accounting Policies [Text Block] Summary of Significant Accounting Policies Fair Value Measurement Fair Value Disclosures [Text Block] Fair Value Measurement Property and Equipment, net Property, Plant and Equipment Disclosure [Text Block] Property and Equipment, net Prepaid Expenses and Other Current Assets The entire disclosure for prepaid expenses and other current assets. Prepaid Expenses and Other Current Assets [Text Block] Prepaid Expenses and Other Current Assets Other Current Liabilities Other Liabilities Disclosure [Text Block] Other Current Liabilities Stock-Based Compensation Share-based Payment Arrangement [Text Block] Stock-Based Compensation Net Loss Per Share Earnings Per Share [Text Block] Net Loss Per Share Leases Lessee, Operating Leases [Text Block] Leases Commitments and Contingencies. Commitments and Contingencies Disclosure [Text Block] Commitments and Contingencies Disclosure of accounting policy for basis of presentation and consolidation. Basis of Presentation and Consolidation, Policy [Policy Text Block] Basis of Presentation and Consolidation Disclosure of accounting policy for unaudited interim financial information . Unaudited Interim Financial Information, Policy [Policy Text Block] Unaudited Interim Financial Information Use of Estimates, Policy [Policy Text Block] Use of Estimates Cash and Cash Equivalents, Policy [Policy Text Block] Cash and Cash Equivalents Marketable Securities, Policy [Policy Text Block] Marketable Securities Concentration Risk, Credit Risk, Policy [Policy Text Block] Concentration of Credit Risk and Other Risks and Uncertainties Lessee, Leases [Policy Text Block] Leases Research and Development Expense, Policy [Policy Text Block] Research and Development Costs Disclosure of accounting policy for research contract costs and accruals . Research Contract Costs and Accruals, Policy [Policy Text Block] Research Contract Costs and Accruals Earnings Per Share, Policy [Policy Text Block] Net Loss Per Common Share New Accounting Pronouncements, Policy [Policy Text Block] Recent Accounting Pronouncements Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] Schedule of financial assets and liabilities measured at fair value on a recurring basis Schedule of Available-for-sale Securities Reconciliation [Table Text Block] Schedule of financial assets reconciliation Property, Plant and Equipment [Table Text Block] Schedule of property and equipment, net Tabular disclosure of the carrying amounts of prepaid expenses and other current assets. Schedule of Prepaid Expenses and Other Current Assets [Table Text Block] Schedule of prepaid expenses and other current assets Other Current Liabilities [Table Text Block] Schedule of other current liabilities Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Schedule of fair value assumptions Share-based Payment Arrangement, Option, Activity [Table Text Block] Schedule of stock option activity Schedule of Unvested Restricted Stock Units Roll Forward [Table Text Block] Summary of restricted stock activity Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] Schedule of stock-based compensation expense Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Schedule of basic and diluted net loss per share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Schedule of anti-dilutive securities excluded from computation of diluted loss per share Lease, Cost [Table Text Block] Summary of total lease expense Tabular disclosure of supplemental cash flow information of lessee's operating lease. Summary of Supplemental Cash Flow Information [Table Text Block] Summary of supplemental cash flow information Lessee, Operating Lease, Liability, Maturity [Table Text Block] Summary of future minimum lease payments Tabular disclosure of lease term and discount rate of lessee's operating lease. Summary of Lease Term and Discount Rate [Table Text Block] Summary of lease term and discount rate Number of Operating Segments Number of operating segments Number of Reportable Segments Number of reportable segments Cash, Cash Equivalents, and Short-term Investments Cash, cash equivalents and marketable securities Fair Value, Recurring and Nonrecurring [Table] Financial Instrument [Axis] Financial Instruments [Domain] U.S. Government treasury bills Government-sponsored enterprise securities Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Domain] Money market funds Commercial paper Measurement Frequency [Axis] Measurement Frequency [Domain] Recurring Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Domain] Level 1 Level 2 Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Assets, Fair Value Disclosure [Abstract] Assets Cash and Cash Equivalents, Fair Value Disclosure Cash